PT-141, NAD, and Glutathione-What the heck are they?

January 15, 2025

PT-141 (Bremelanotide), Nicotinamide Adenine Dinucleotide (NAD), and glutathione are compounds with distinct therapeutic applications and benefits in medical treatments.

PT-141 (Bremelanotide):

Bremelanotide is a melanocortin receptor agonist approved by the U.S. Food and Drug Administration for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. It works by activating melanocortin receptors in the central nervous system, particularly the hypothalamus, to enhance sexual desire and arousal. Clinical trials, such as the RECONNECT studies, have demonstrated that bremelanotide significantly improves sexual desire and reduces distress related to low sexual desire in premenopausal women with HSDD.[1-2] It is administered subcutaneously as needed before sexual activity.

Nicotinamide Adenine Dinucleotide (NAD):

NAD is a critical coenzyme involved in cellular energy production, redox reactions, and signaling pathways that regulate aging and health span. NAD levels decline with age, contributing to various age-related diseases. Supplementation with NAD precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), has shown promise in improving metabolic health, reducing oxidative stress, and enhancing mitochondrial function. Early human studies suggest benefits in preventing nonmelanotic skin cancer, reducing blood pressure, improving lipid profiles, and suppressing inflammation in conditions like Parkinson’s disease and SARS-CoV-2 infection.[3-5] However, more research is needed to fully understand the therapeutic mechanisms and optimize clinical applications. NAD can be given IV or as an injection.

Glutathione:

Glutathione (GSH) is a potent intracellular antioxidant that plays a crucial role in maintaining cellular redox balance, detoxifying xenobiotics, and regulating immune function. It is involved in protecting cells from oxidative damage and supporting various physiological processes. Glutathione supplementation has been explored for its potential benefits in treating conditions such as acute respiratory distress syndrome, liver disease, and cancer. Elevated GSH levels in tumor cells are associated with increased resistance to chemotherapy, leading to the development of therapies targeting the GSH antioxidant system to enhance treatment efficacy.[6-8] Glutathione’s role in reducing oxidative stress and supporting immune function makes it a valuable therapeutic agent in various clinical settings.

In summary, PT-141 (Bremelanotide) is primarily used for treating HSDD in premenopausal women, NAD supplementation shows potential in addressing age-related metabolic and neurodegenerative conditions, and glutathione is a key antioxidant with applications in managing oxidative stress and enhancing immune function.

Indy Elite Men’s T Clinic and Indy Elite IV Drip and Wellness offer PT-141, NAD, and Glutathione. Visit IndyIVDrip.com-iv-hydration-and-add-ons for more information.

References

1.Prespecified and Integrated Subgroup Analyses From the RECONNECT Phase 3 Studies of Bremelanotide.

Simon JA, Kingsberg SA, Portman D, et al.

Journal of Women’s Health (2002). 2022;31(3):391-400. doi:10.1089/jwh.2021.0225.

2.Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials.

Kingsberg SA, Clayton AH, Portman D, et al.

Obstetrics and Gynecology. 2019;134(5):899-908. doi:10.1097/AOG.0000000000003500.

3.Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns.

Bhasin S, Seals D, Migaud M, Musi N, Baur JA.

Endocrine Reviews. 2023;44(6):1047-1073. doi:10.1210/endrev/bnad019.

Leading Journal

4.NAD Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging: Mechanisms and Therapeutic Implications.