Over-the-counter (OTC) testosterone boosters and testosterone supplements are widely marketed for their purported benefits in enhancing muscle mass, strength, and libido. These products often contain a variety of ingredients, including herbal extracts (e.g., Tribulus terrestris, fenugreek), vitamins, minerals, and sometimes undisclosed anabolic steroids or prohormones.
Effectiveness: The effectiveness of OTC testosterone boosters and testosterone supplements is generally not well-supported by robust clinical evidence. Many of the herbal ingredients lack substantial clinical trials demonstrating significant increases in testosterone levels or improvements in muscle mass and strength. For example, prohormones like androstenedione and dehydroepiandrosterone (DHEA) do not consistently increase blood testosterone concentrations or muscle size.[1]
Safety Profile and Liver Function: The safety profile of these supplements is concerning. Some OTC testosterone boosters and testosterone supplements have been associated with significant adverse effects, particularly on liver function. For instance, a study reported toxic hepatitis in bodybuilders using dietary supplements containing testosterone optimizers. Additionally, the presence of undisclosed anabolic steroids in some supplements can lead to severe hepatic adverse effects, including cholestatic jaundice and liver tumors. The American Urological Association (AUA) guidelines highlight the risk of liver toxicity with the use of 17-alpha-alkylated androgens, which are sometimes found in these products.[2-5]
Regulatory Concerns: The lack of rigorous oversight in the supplement industry means that the composition of these products can be inconsistent, and contamination with anabolic steroids is not uncommon. This underscores the need for caution and more stringent regulation.[3]In summary, the use of OTC testosterone boosters and testosterone supplements is not recommended due to their questionable effectiveness and potential for serious adverse effects, particularly on liver function. Clinicians should advise patients to avoid these supplements and consider medically supervised testosterone replacement therapy if indicated.
When it comes to hormone health, working with an experienced provider is essential. Testosterone boosters and testosterone supplements taken without proper guidance can disrupt your natural hormone balance, leading to unwanted side effects like mood swings, cardiovascular issues, and liver damage. An experienced provider can evaluate your overall health, monitor your hormone levels, and create a tailored plan that ensures safety and effectiveness using safe TRT. Trusting a professional protects your health and helps you achieve the best possible outcomes. Call 317-762-0030 or visit www.IndyEliteMensT.com for more information.
References
1.Promotion of Healthy Weight-Control Practices in Young Athletes.
Carl RL, Johnson MD, Martin TJ.
Pediatrics. 2017;140(3):e20171871. doi:10.1542/peds.2017-1871.
2.Toxic Hepatitis in a Group of 20 Male Body-Builders Taking Dietary Supplements.
Timcheh-Hariri A, Balali-Mood M, Aryan E, Sadeghi M, Riahi-Zanjani B.
Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association. 2012;50(10):3826-32. doi:10.1016/j.fct.2012.07.006.
3.Androgenic Steroids in Over-the-Counter Dietary Supplements: Analysis for Association With Adverse Health Effects.
Tran BN, Okoniewski R, Spink BC, et al.
Steroids. 2023;193:109199. doi:10.1016/j.steroids.2023.109199.
4.17beta-Hydroxy-5alpha-Androst-1-en-3-One (1-Testosterone) Is a Potent Androgen With Anabolic Properties.
Friedel A, Geyer H, Kamber M, et al.
Toxicology Letters. 2006;165(2):149-55. doi:10.1016/j.toxlet.2006.03.001.
5.Evaluation and Management of Testosterone Deficiency: AUA Guideline.
Mulhall JP, Trost LW, Brannigan RE, et al.
The Journal of Urology. 2018;200(2):423-432. doi:10.1016/j.juro.2018.03.115.